Unless they want someone that can hit the ground running in a specific language. In order to do that requires some knowledge about the language.A good employer should understand that it's not so much about your experience in specific languages, ...
However they usually will make concessions if the candidate demonstrates a good overall knowledge since they understand that knowledge could bring the candidate up to speed on a specific one in little time.
I used to let those HR postings scare me and deter me but after some very good advice from the members here I went ahead and applied to them anyways. After a bit of time I was finally offered the chance to interview and eventually landed the job. After having been through all that and involved in the hiring process I would never advise someone not turn in a resume just b/c they did not meet every qualification in the posting. They won't bring you in if they feel your qualifications don't meet what the position requires. The worst they can do is not call you which happens every single day. One thing for sure is if you never apply there is a 100% chance they won't call you.