Disabling Serial Handshaking

I need to disable all the handshaking for the serial port. What settings of the serial port are the handshaking? I'm relatively new to this area...

For windows take a look at this Serial Communications in Win32

search for handshaking

Thanks vart - However I'm not using Win32, I'm writing software to run on a DOS only computer. I know what I need to disable, I'm just not sure how to do it. I have to set the bits manually, but I'm not sure which ones to set. I originally thought it was the Modem Control Register, but after searching, I'm not so sure.