Dijkstra quote is:
The interpretation I make of this is not that of negating the relevance of Computer Science on computers. He merely tries to remind us that the Computer Science field is much bigger than its tools. We also know the context where he put this phrase and can safely say that the quote is a direct defense to his belief that the act of programming is merely a tool of Computer Science, or even the application of the Computer Science field in everyday life. Programming is simply executing previously gained knowledge.“Computer science is no more about computers than astronomy is about telescopes.”
Ironically enough this quote is a double-edged sword. It didn't stop him -- neither it could -- from being so anal about several programming languages of his time. So a tool is, according to him, still a possible subject of analysis.
This puts the argument "all programming languages (within reason) are created equal" that I and others defend to the test. Personally I find Dijkstra went a little overboard on this letter. Probably not his proudest moment. The human mind is thankfully a lot more adaptable than that and one can evolve their skills from bad programming languages into good programming languages over the course of a single programming career. The thought that once you learn BASIC as your first language you are forever doomed into mediocrity is a bad argument. It is in fact negating the value of an entire generation of programmers. It is also not really very compatible with the tens of thousands of years of human history in which new and better knowledge was gained on the foundation of old and bad knowledge. How could this be, if we were doomed to not adapt to new knowledge?
But I don't entirely deny the value of his arguments (that programming languages are subject of criticism). I personally feel languages such as Java inferior in a few respects. Some more important than others. And I still have yet to understand why the insistence in creating interpreted programming languages. However I cannot deny their ability to produce software. And this is where the debate begins.